Evidence from hematological and epigenomic profiling shows that acute hypoxia inhibits blood glycolysis in saker falcons (Falco cherrug) through NR3C1-mediated regulation of HK1.

• N Venkata Rāo

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High-altitude bird species are moving to even
higher elevations due to ongoing climate change,
but little is known about the physiological and
regulatory responses that allow these migrations.
By subjecting saker falcons (Falco cherrug) that
live on the Qinghai-Xizang Plateau to simulated
altitudes of 5,000–6,000 meters above sea level
(a.s.l.), which is higher than their normal range of
elevations (about 4,300 meters a.s.l.), this study
examined acute hypoxia responses in these birds.
Juvenile falcons maintained similar activity levels
over the 4 000–5 000 m and 5 000–6 000 m a.s.l.
ranges, according to GPS monitoring data.

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