Through the mir-130b-5p/ASH1L pathway, CircSHOC2 controls the production of steroid hormones in ovarian granulosa cells.

• P Sujatha

  English

  Author

• P Dhavachelvan

  English

  Author

A crucial stage of the pig reproductive cycle,
estrus depends on coordinated steroidogenesis
and healthy ovarian growth. By secreting
progesterone (P4) and estradiol (E2), which are
necessary for follicular maturation and ovulatory
competence, granulosa cells (GCs) mediate these
processes. Circular RNAs (circRNAs) have been
linked to the manufacture of steroid hormones,
although it is yet unknown how they affect the
estrous control. 

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