Current studies on the method of action and clinical efficacy of St. John's wort

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• sandar

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• Lewis

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In several nations, preparations made from St. John's wort extracts are used to treat depression as a recognized 
substitute for behavioral therapy or synthetic antidepressants. As a result, the therapeutic application of St. 
John's wort extracts goes far beyond the conventional realm of herbal therapy. A summary of the state of 
preclinical and clinical research is provided. The neuronal absorption of gamma-aminobutyric acid (GABA), 
L-glutamate, noradrenaline, dopamine, and serotonin is all clearly inhibited by St. John's wort extract. No 
other antidepressant exhibits an inhibitory profile that is roughly as extensive. Numerous effects in several 
behavioral pharmacology models of antidepressant efficacy could also be shown for St. John's wort extract, in 
good agreement with the effects in various biochemical models of antidepressant action. The aforementioned 
neurotransmitter systems in the brain are likewise altered by comparable dosages of John's wort.hyperforin

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