Isonicotino hydrazide's anti-TB activity: spectroscopic and computational (DFT-SCF) studies

• Diego Rivera a,n

  English

  Author

• Robert Allkin

  English

  Author

The antibiotic chemical isoniazid, also known as isonicotino hydrazide, is used as a first-line therapy and preventative
measure for both active and latent tuberculosis [1]. When it comes to Mycobacteria, especially Mycobacterium tuberculosis,
this chemical molecule works well. Additionally, it exhibits activity against certain atypical mycobacteria [2]. There are three
types of isonicotino hydrazide: tablets, syrups, and injectables [3–4]. It was thought to be a good place to start when looking
for novel active derivatives and analogues, like hydrazones, which have been shown to be effective anti-TB medications [5–
6]. Isonicotino hydrazide is a pro drug that requires bacterial catalysis to activate. In particular, hydrazine’s reduction of the
mycobacterial ferric Kat G catalase-peroxidase and its reaction with oxygen to generate an oxyferrous enzyme complex are
linked to activation. Isonicotino hydrazide, once activated, prevents the production of mycoloic acids, which are vital for the
bacterial cell wall. Isoniazid is bacteriocidal against Mycobacterium TB organisms that are actively developing both inside
and outside of cells at therapeutic concentrations

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