Propranolol Hydrochloride Transdermal Patch Design and Development: In Vitro and Ex Vivo Evaluation

• A ASaritha

  English

  Author

• Vikram Varma

  English

  Author

In general, transdermal medication administration refers to the topical application of substances to healthy, intact
skin for either systemic therapy or localized treatment of the tissues beneath the skin. The objective of dosage design
for transdermal medicines is to limit drug retension and metabolism in the skin while simultaneously optimizing
the flux through the skin into the systemic circulation. Transdermal drug delivery devices are self-contained,
discrete dose forms that are placed to undamaged skin and allow the medications to enter the bloodstream at a
regulated pace. When compared to oral administration, transdermal medication delivery offers numerous benefits.
For example, it increases absolute bioavailability by avoiding first-pass hepatic and gastrointestinal processing.
increased effectiveness of treatment, decreased adverse effects as a result of blood concentration-time profile
modification, Therapeutic agents are given through the skin at a controlled rate into the systemic circulation,
resulting in a rapid termination of drug action by removing the drug application from the skin's surfaces.
Materials and Procedures
Propranolol hydrochloride, sodium hydroxide, potassium dihydrogen orthophosphate, methanol, dichloromethane,
HPMC E15, PEG-400, and calcium and aluminum chloride, as well as a dialysis membrane.

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