Resveratrol's Effect on Naproxen's Pharmacokinetics and Pharmacodynamics: Role of CYP1A2 Inhibition

• Emiel Caron

  English

  Author

• Nees Jan van Eck

  English

  Author

Naproxen (NAP) (6-methoxy-α-methyl-2-napthalene acetic acid) is a non-steriodal anti-inflammatory medication
that works well as an analgesic (Ruedy and Mcullongh 1973) and for rheumatoid arthritis (Bowers et al. 1975). The
plasma concentrations of naproxen are correlated with its effectiveness (Day et al., 1982). Due to its strong binding
to plasma albumin, naproxen is mostly concentrated in plasma (Runkel et al. 1972) and is well absorbed orally at
dosages up to 900 mg (Runkel et al. 1974). (Brogden et al. 1984) Naproxen belongs to the 2-arylpropionic acid class
of nonsteroidal anti-inflammatory drugs and is stereochemically pure. When used orally, naproxen is quickly and
completely absorbed. Only a little portion of naproxen is removed unaltered after biotransformation into
glucuroconjugated and sulphate metabolites, which are eliminated in urine. Since buildup happens in end-stage renal
illness, the excretion of the 6-0-desmethylnaproxen metabolite conjugate may be related to renal function.

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