A spectroscopic study with implications for pharmacological analysis on the improvement of isoflavones' water solubility through complexation with modified cyclodextrins

• Xin Sun

  English

  Author

• Chen Yang

  English

  Author

The enhanced bioavailability of isoflavones through complexation with chemically modified cyclodextrins 
(CyDs) has been utilized to analyze the drug/macrocycle binding affinity using a traditional approach and new 
practical metrics. In aqueous medium and with varying host/guest molar ratios of (2-hydroxypropyl)-β
cyclodextrin (HP-β-CyD), genistein (Gen) and daidzein (Daidz) were studied. By dividing the guest molecule 
between water and the organic solvent, the solubility in pure water was found to be approximately 3 × 10−6 M 
for Gen and approximately 10 × 10−6 M for Daidz. Phase-solubility UV–vis measurements and circular 
dichroism data have corroborated the stoichiometric ratios and stability constants that describe the degree of 
complex formation. The determination of the carrier's ability to compound the medication in aqueous solution is 
affected by these findings.

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