Formulation and Evaluation of Cefpodoxime Proxetil Buccal Film

• Aditya Chandrashekhar

  English

  Author

A new method of administering drugs is through the buccal mucosa. Compared to pills, buccal films are
more flexible and easier for patients to tolerate. Therefore, it was intended to use chitosan, gelatin, and
pectin as the primary polymeric substrates to create buccal films containing cefpodoxime proxetil. It can
be used to treat infections of the skin, soft tissues, urinary tract, and respiratory system brought on by both
gram-positive and gram-negative bacteria. Seven formulations were created using the solvent casting
process after a number of pre-formulation investigations, including solubility and infrared spectroscopy,
were completed. In addition to mechanical evaluations like tensile strength and elongation at break,
physical evaluations including physical appearance and surface texture, weight variation, mean thickness,
swelling index, folding endurance, surface pH, and moisture loss & moisture absorption investigations
were conducted. Using the polymers chitosan, hydroxypropyl methyl cellulose, polyvinylpyrrolidone, and
propylene glycol as plasticizers, F6 was chosen as the optimal film based on the in vitro dissolution
investigations, which showed a maximum cumulative drug release of 98.91% for up to 390 minutes.
Additional tests, including stability, antimicrobial, and release kinetics, were computed for the optimized
film and were determined to be within the limit

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