Synthesized novel N10-alkyl substituted acridine-9-one derivatives' antimicrobial activity

• T. Aruna Malapati

  English

  Author

A significant class of chemotherapeutic medications and dyes, acrylidine and its derivatives are
bacteriostatic and bactericidal to both Gram-positive and Gram-negative organisms. 1–2. A derivative of
acridine, acridin-9-(10H)-one is an intriguing tricyclic nitrogen-containing heterocyclic molecule that was
initially utilized to treat malaria in the 19th century3. Alkaloids containing acridone have been identified
in the bark and leaves of a number of trees, including Melicopoe fareana and Evodia xanthoxyloids.
Melicopicine, melicopidine, and eroxanthine4 are significant alkaloids discovered in the woods of
Queensland, Australia. Numerous biological actions, including antileishmanial, anticancer, anti-HIV, and
antibacterial properties, have been identified for acridone. Acridone5 is also linked to poor bioavailability
and medication resistance.

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