The Possibility of Paracetamol-Related Drug Interactions in a Group of Hospitalized Elderly Patients

• C Bhargavi

  English

  Author

This study evaluates the clinical impact of paracetamol use in patients hospitalized to a geriatric
medicine department, as well as the risk of possible drug-drug interactions. Techniques. Patients who had
been taking paracetamol at the time of or during their hospital stay were the subjects of a retrospective and
longitudinal investigation. The included patients' hospital records were examined, including records of
concurrent prescriptions, diagnoses, biochemical readings, and unfavorable events that occurred while they
were in the hospital. When determining the clinical likelihood impact of the discovered drug-drug
interactions, these metrics served as a clinical follow-up. outcomes. Over the course of the trial, 104
individuals were admitted in total. Of these, 91 (87.5%) had a prescription or had paracetamol treatment
(mean age 86 years). Ten percent of these were deemed to be at risk for possible drug-drug interactions
with paracetamol. Treatments with warfarin, valsartan, and phenytoin were linked to seven of the possible
drug-drug interactions. Six of the nine at-risk patients did either have abnormal biochemical levels or
possible clinical occurrences associated with them. Among the four patients with elevated INR (range 3.2–
4.6), one had hematemesis and the other anemia. Increased ALAT/ASAT was seen in two patients (55/42
U/I and 87/51 U/I, both female). One person had high blood pressure. In conclusion. In this study,
paracetamol was used to treat the vast majority of the patients. During their hospital stay, six patients were
assessed for either clinical occurrences or aberrant biochemical results that might have been caused by the
possible drug-drug interactions that were found.

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