The Etiology and Pathophysiology of Major Human Diseases Are Unified by Aberrant Free Radical Biology

• A Govindankutty

  English

  Author

The abnormal generation and/or elimination of biologically produced free radicals and other
reactive oxygen and nitrogen species (ROS/RNS) is now known to be a common trait across the
apparently unrelated fields of oxygen toxicity, radiation exposure, and aging. Clinically feasible
diagnostic and therapeutic applications have been and still are being developed from advances in our
knowledge of the impact of free radicals in biology and medicine. Recent developments in the study of
free radicals in biology and medicine, including fundamental findings and practical applications, are the
focus of this issue. Much more will be discovered about the similarities in the processes driving
apparently different disease states as we get a better understanding of the proximal biological targets of
reactive substances that are created or eliminated abnormally, as well as their sensors and effectors of
compensatory response. Opportunities to develop logical treatment approaches to lessen the prevalence
and severity of these illnesses and enhance human health will present themselves along with this
increased knowledge.

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