Aberrant Free Radical Biology Is a Unifying Theme in the Etiology and Pathogenesis of Major Human Diseases

• Frederick E. Domann

  English

  Author

The seemingly disparate areas of oxygen toxicity, radiation exposure, and aging are
now recognized to share a common feature—the aberrant production and/or removal of
biologically derived free radicals and other reactive oxygen and nitrogen species (ROS/RNS).
Advances in our understanding of the effects of free radicals in biology and medicine have been,
and continue to be, actively translated into clinically tractable diagnostic and therapeutic
applications. This issue is dedicated to recent advances, both basic discoveries and clinical
applications, in the field of free radicals in biology and medicine. As more is understood about the
proximal biological targets of aberrantly produced or removed reactive species, their sensors, and
effectors of compensatory response, a great deal more will be learned about the commonalities in
mechanisms underlying seemingly disparate disease states. Together with this deeper
understanding, opportunities will arise to devise rational therapeutic interventions to decrease the
incidence and severity of these diseases and positively impact the human healthspan.

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