Hydrogel Based on Poly (N-isopropylacrylamide) and Its Use as a Delivery System for Anti-Diabetic Medications: How It Swells and How It Works

• Danjatau G. Nkafamiya Y

  English

  Author

• Adeleye T. Aderemi

  English

  Author

We directly weigh the hydrogel containing charantin from poly (N-isopropyl acrylamide) PNIPAM before soaking it in a fluid/drug solution in a
temperature-controlled water bath to achieve the swelling kinetics. The research was conducted with the intention of using the findings as a
delivery mechanism for drugs used to treat diabetes. The bitter melon fruit and leaves were subjected to a pH control process in order to extract
charantin. An increase in the lower critical solution temperature (LCST) from 32-43 ℃ was seen in distilled water when the acrylamide
concentration was varied between 3 and 12% during PNIPAM synthesis, suggesting a direct link. Hydrogel LCST was shown to decrease as the
polarity of the solution increased, as demonstrated by the effects of switching between pure water, insulin, and charantin solutions. The hydrogels
N1, N2, N3, and N4 had charantin loadings of 42.51, 44.57, 43.55, and 44.61 μg/mL, respectively, when immersed in a charantin solution with a
concentration of 52.61 μg/mL. There is a physical connection between the hydrogel matrix and the charantin molecules, accordi ng to the
hydrogels' FTIR spectroscopy characterization. Hydrogels exhibited diffusivity values between 1.48 x 10⁴ and 5.08 x 10⁴ M2/s, and release
exponents of > 0.5 suggested non-Fickian diffusional release.

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